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SOAL
1. What is excretion?
17. What is the main transformation presented in glomerular filtrate compared to blood?
24. How are the kidneys involved in controlling blood volume? How is the volume of blood in the body related to arterial pressure?
29. What evolutionary hypothesis could explain the heart’s role in secreting a hormone that regulates renal function? What hormone is this?
SOAL
1. What is excretion?
- In Physiology, excretion is the process of the elimination of metabolic wastes and other toxic substances from the body.
- Nitrogenous wastes are residues produced by the degradation of proteins. They are produced by chemical transformations in the amine group of amino acid molecules.
- The main nitrogenous wastes excreted by living organisms are ammonia, uric acid and urea.
- Living organisms that secrete ammonia are called ammonotelic.
- Organisms that secrete uric acid are called uricotelic.
- Organisms that secrete urea are called ureotelic.
- Aquatic animals, such as crustaceans, bony fish and amphibian larvae, are generally ammonotelic because ammonia diffuses more easily through membranes and is more water-soluble than the other types of nitrogenous waste.
- Ammonia is still the nitrogenous waste most economical to synthesize in terms of energy.
- Ammonia is a highly toxic molecule if not diluted and quickly excreted from the body.
- For this reason, ammonotelic excretion was abandoned in terrestrial habitats because the availability of water for dilution was reduced in this medium, making it so that waste could not be excreted to the exterior so quickly.
- Urea is more water-soluble than uric acid (an almost insoluble substance).
- Urea is also more toxic. However, both are less toxic than ammonia.
- Some invertebrates, chondrichthyan fish, adult amphibians and mammals are ureotelic. Reptiles, birds and most arthropods are uricotelic.
- Since amphibian larvae are aquatic, they excrete ammonia. The terrestrial adult excretes urea.
- In reptiles and birds, the excretory system is uricotelic since uric acid is insoluble, less toxic and suitable to be stored within the eggs where their embryos develop.
- Placental animals, including embryos, excrete urea.
- In the adult placental mammal urea is excreted through the urine.
- In embryos, the molecule passes to the mother’s blood through the placenta and is excreted in the mother’s urine.
- Human beings excrete mainly urea, which is eliminated in urine.
- Urea is a product of the degradation of amino acids.
- During this process, amino acids lose their amine group, which is then transformed into ammonia.
- In the liver, ammonia reacts with carbon dioxide to form urea and water, through a process called ureogenesis.
- During the intermediary reactions of ureogenesis, a molecule of ornithine is consumed and another is produced. For this reason, ureogenesis is also known as the ornithine cycle.
- The excretory system is formed of the kidneys (two), the ureters (two), the bladder and the urethra.
- The renal arteries are branches of the aorta; therefore, blood filtered by the kidneys is arterial (oxygen-rich) blood.
- The venous vessels that collect blood filtered by the kidneys are the renal veins.
- The renal veins carry blood that has been reabsorbed by the nephron tubules.
15. What is the functional unit of the kidneys?
- The functional (filtering) unit of the kidneys is the nephron.
- A nephron is made of the afferent arteriole, the efferent arteriole, the glomerulus, the Bowman's capsule, the proximal tubule, the loop of Henle, the distal tubule and the collecting duct.
- Urine is made by these occurrence of three processes in the nephron: glomerular filtration, tubular reabsorption and tubular secretion.
- In the nephron, blood carried by the afferent arteriole enters the glomerular capillary network where it is filtered.
- The filtration results in part of the blood returning to circulation through the efferent arteriole while the other part, known as glomerular filtrate, enters the proximal tubule of the nephron.
- In the nephron tubules (also known as convoluted tubules), substances of the glomerular filtrate, such as water, ions and small organic molecules, are reabsorbed by the cells of the tubule wall and enter into circulation. \
- These cells also secrete other substances inside the tubules.
- Urine is formed of filtered substances that are reabsorbed and of secreted (by the tubules) substances.
- Urine is drained by the collecting ducts to the ureter of each kidney.
- It then enters the bladder and is later discharged through the urethra.
- The nephron tubules are surrounded by an extensive capillary network that collects reabsorbed substances and supplies others to be secreted.
17. What is the main transformation presented in glomerular filtrate compared to blood?
- Glomerular filtrate is the name given to plasma after it has passed the glomerulus and entered the Bowman’s capsule.
- Glomerular filtrate has a different composition compared to urine, since the fluid has not yet undergone tubular reabsorption and secretion.
- The main difference between blood and glomerular filtrate is that the latter contains a minimum amount of proteins as well as no cells or blood platelets.
- Proteinuria means the passing of proteins in the urine. Under normal conditions, proteins are too large to be filtered by the glomerulus and are practically absent in urine (the few filtered proteins may also be reabsorbed by the nephron tubules).
- Proteinuria is an indication that a more than expected amount of proteins is passing through the glomerulus, and is an indicator of glomerular disease, such as diabetic nephropathy.
- The glomerulus also blocks the passage of blood cells and platelets (hematuria is often a sign of urinary disease, although it does not specifically implicate the kidneys, since the blood may come from the lower parts of the excretory tract).
- Only 0.5 to 1% of glomerular filtrate is eliminated as urine.
- The remaining volume, containing mainly metabolic ions, glucose, amino acids and water, is reabsorbed by the nephron tubules (by means of active or passive transport) and regains blood circulation.
- The cells of the tubule wall have a large number of mitochondria because many substances are reabsorbed or secreted through them by means of active transport (a process that spends energy).
- Therefore, many mitochondria are necessary to supply the energy for (ATP supply) this type of transport.
- Tubular secretion is the passage of substances from the blood capillaries that surround the nephron tubules to the tubular lumen so that these substances can be excreted with urine.
- Ammonia, uric acid, potassium, bicarbonate and hydrogen ions, metabolic acids and bases, various ingested drugs (medicines) and other substances are secreted by the nephron tubules.
- The regulation of the acid-basic equilibrium of the body is carried out by the kidneys and depends on tubular reabsorption and secretion.
- How are alkalosis and acidosis corrected by the kidneys?
- The kidneys can regulate the acidity or alkalinity of the plasma by varying the excretion of hydrogen and bicarbonate ions.
- During alkalosis (an abnormally high level of plasma pH), the kidneys excrete more bicarbonate ions and the equilibrium of the formation of bicarbonate from water and carbon dioxide shifts towards the formation of more hydrogen ions and bicarbonate ions, thus lowering plasma pH.
- When the body undergoes acidosis (an abnormally low level of plasma pH), the kidneys excrete more hydrogen ions and retain more bicarbonate ions and, as a result, the equilibrium of the formation of bicarbonate from water and carbon dioxide shifts towards more hydrogen consumption, increasing the pH of plasma.
24. How are the kidneys involved in controlling blood volume? How is the volume of blood in the body related to arterial pressure?
- The kidneys and the hormones that control them are the main physiological regulators of the total volume of blood in the body.
- As more water is reabsorbed by the nephron tubules, the volume of blood increases and, as more water is excreted in urine, the volume of blood lowers.
- The volume of blood in turn has a direct relationship with blood pressure. Blood pressure increases when blood volume increases and it lowers when blood volume lowers.
- This is the reason why one of the main groups of antihypertensive drugs is diuretics.
- Doctors often prescribe diuretics to patients with high blood pressure so that they excrete more water and therefore lower their blood pressure.
- Antidiuretic hormone (ADH, or vasopressin), aldosterone and atrial natriuretic factor (or ANF) are the mains hormones that are involved in the regulation of the excretory system.
- Antidiuretic hormone is secreted by the hypophysis (also known as the pituitary gland) and it has an effect on the nephron tubules, increasing their reabsorption of water.
- When the body needs to retain water, for example, in the case of blood loss and an abrupt decrease in blood pressure, or in the case of an abnormally high blood osmolarity, ADH secretion is stimulated.
- When the body has an excess of water, such as in the event of excessive ingestion or abnormally low blood osmolarity, the secretion of ADH is blocked and diuresis increases.
- ADH is also known as vasopressin since it increases blood volume and therefore increases blood pressure.
- Alcohol inhibits the secretion of ADH (antidiuretic hormone) by the pituitary gland. That is why when people are drunk, they urinate in excess.
- Aldosterone is a hormone that has an effect on the nephron tubules, stimulating the reabsorption of sodium.
- Therefore, it contributes to increasing blood osmolarity, consequently increasing blood pressure.
- Aldosterone is made by the adrenal glands, which are located above the upper portion of the kidneys.
29. What evolutionary hypothesis could explain the heart’s role in secreting a hormone that regulates renal function? What hormone is this?
- The renal regulator hormone secreted by the heart is atrial natriuretic factor (or ANF).
- ANF increases the excretion of sodium in the nephron tubules, causing less reabsorption of water and more urinary volume, thus lowering blood pressure.
- Atrial natriuretic factor is secreted when there is an increase in the length of heart muscle fibers in response to high blood pressure. ANF is a natural antihypertensive substance.
- Since the health of the heart depends largely on the stability of normal blood pressure, evolution likely preserved atrial natriuretic factor to allow information from the heart to work as an additional mechanism in the renal control of blood pressure.
TRY AGAIN
1. Mengapa tanaman menghasilkan karbon dioksida dan
oksigen?
A. Karbon
dioksida adalah produk limbah respirasi dan oksigen adalah produk limbah
fotosintesis
B. Karbon
dioksida adalah produk limbah fotosintesis dan oksigen adalah produk limbah
respirasi
C. Karbon
dioksida dan oksigen adalah produk limbah fotosintesis
2. Manakah dari berikut ini yang merupakan fungsi penting
stomata dalam daun
A. Menyerap
uap air dari udara
B. Mengizinkan
produk limbah gas meninggalkan pabrik
C. Memproduksi
klorofil untuk fotosintesis
3. Zat apa yang dikeluarkan dari paru-paru?
A. Uap
air
B. Urea
C. Garam
berlebih
4. Apa yang terkandung dalam urin?
A. Hanya
air dan urea
B. Air
dan garam saja
C. Air,
urea, dan garam
5. Tabung mana dalam sistem kemih yang mengalir dari
ginjal ke kandung kemih?
A. Saluran
pengumpul
B. Ureter
C. Uretra
6. Di mana glomerulus ditemukan?
A. Di
sekitar tubulus berbelit-belit
B. Di
lingkaran Henle
C. Di
kapsul Bowman
7. Apa isi filtrat dalam kapsul Bowman?
A. Air,
ion, urea, dan protein
B. Air,
ion, urea, dan glukosa
C. Air,
urea, ion, dan sel darah merah
8. Di mana reabsorpsi glukosa secara selektif terjadi di
nefron ginjal?
A. Dalam
tubulus berbelit-belit proksimal (pertama)
B. Di
tubulus berbelit-belit distal (kedua)
C. Di
saluran pengumpul
9. Apa yang terjadi jika plasma darah terlalu
terkonsentrasi?
A. ADH
yang lebih sedikit dilepaskan, menyebabkan lebih banyak air yang diserap
kembali di nefron
B. Lebih
banyak ADH dilepaskan, menyebabkan lebih sedikit air yang diserap kembali di
nefron
C. Lebih
banyak ADH dilepaskan, menyebabkan lebih banyak air diserap kembali di nefron
10. Pembuluh darah mana yang memasok ginjal?
A. Arteri
hati
B. Arteri
ginjal
C. Arteri
paru
11. Limbah metabolik apa yang tidak dibuang selama
ekskresi?
A. Limbah
Nitrogenous
B. CO2
C. H2O
D. Urea
12. Manakah
dari berikut ini BUKAN salah satu dari empat langkah yang digunakan nefron
untuk menjalankan fungsinya?
A. Penyaringan
B. Reabsorpsi
C. Augmentasu
D. Reduksi
13. Molekul mana
yang termasuk dalam filtrasi?
A. Glukosa
B. Asam
amino
C. Garam
D. Vitamin
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