1) All hormones
A) are produced by endocrine glands.
B) are lipid-soluble molecules.
C) are carried to target cells in the blood.
D) are protein molecules.
E) elicit the same biological response from all of their
target cells.
Answer: C
2) In a positive-feedback system where hormone A alters
the amount of protein X
A) an increase in A always produces an increase in X.
B) an increase in X always produces a decrease in A.
C) a decrease in A always produces an increase in X.
D) a decrease in X always causes a decrease in A.
E) it is impossible to predict how A and X affect each
other.
Answer: A
3) Testosterone is an example of a chemical signal that
affects the very cells that synthesize it, the neighboring cells in the testis,
along with distant cells outside the gonads. Thus, testosterone is an example
of
A) an autocrine signal.
B) a paracrine signal.
C) an endocrine signal.
D) both an autocrine signal and a paracrine signal.
E) an autocrine signal, a paracrine signal, and an endocrine
signal.
Answer: E
4) Which category of signal exerts its effects on target
cells by binding to membrane-bound receptor proteins?
A) neurohormones
B) estrogens
C) androgens
D) vitamin D
E) neurohormones, estrogens, androgens, and vitamin D
Answer: A
5) A paracrine signal that relaxes smooth muscle cells is
A) nitric oxide.
B) vitamin D.
C) testosterone.
D) cortisol.
E) antidiuretic hormone.
Answer: A
6) Prostaglandins are local regulators whose chemical
structure is derived from
A) oligosaccharides.
B) fatty acids.
C) steroids.
D) amino acids.
E) nitric oxide.
Answer: B
7) Ecdysone is a(n)
A) peptide hormone.
B) amine derivative.
C) steroid hormone.
D) iodinated protein hormone made by the thyroid gland.
E) gaseous neurotransmitter.
Answer: C
8) Aspirin and ibuprofen both
A) inhibit the synthesis of prostaglandins.
B) inhibit the release of nitric oxide, a potent
vasodilator.
C) activate the paracrine signaling pathways that form
blood clots.
D) stimulate the release of oxytocin.
E) stimulate vasoconstriction in the kidneys.
Answer: A
9) A cell with membrane-bound proteins that selectively
bind a specific hormone is called that hormone's
A) secretory cell.
B) plasma cell.
C) endocrine cell.
D) target cell.
E) regulatory cell.
Answer: D
10) The reason that the steroid hormone aldosterone
affects only a small number of cells in the body is that
A) only its target cells get exposed to aldosterone.
B) only its target cells contain aldosterone receptors.
C) it is unable to enter nontarget cells.
D) nontarget cells destroy aldosterone before it can
produce any effect.
E) nontarget cells convert aldosterone to a hormone to
which they do respond.
Answer: B
11) Different body cells can respond differently to the
same peptide hormones because
A) different target cells have different sets of genes.
B) each cell converts that hormone to a different
metabolite.
C) a target cell's response is determined by the
components of its signal transduction pathways.
D) the circulatory system regulates responses to hormones
by routing the hormones to specific targets.
E) the hormone is chemically altered in different ways as
it travels through the circulatory system.
Answer: C
12) Insect hormones and their receptors
A) act independently of each other.
B) are a focus in pest-control research.
C) utilize cell-surface receptors only.
D) are active independently of environmental cues.
E) are not relevant to the study of steroid hormones.
Answer: B
13) Endocrine glands that are sources of steroid hormones
A) secrete the steroids through ducts into the blood.
B) store those hormones in membrane-bound vesicles.
C) have a very short latency between steroid synthesis
and steroid release.
D) are all controlled by the autonomic nervous system.
E) operate independently of other hormonal cuing systems.
Answer: C
14) A chemical signal operating in a paracrine manner is
one that
A) is active at a neuronal synapse.
B) affects only the cells that synthesize the paracrine
signal.
C) requires transport in the blood before it can act on
its target cells.
D) evokes responses from all parts of the vascular
system.
E) must move through the air before it reaches its target
cells.
Answer: A
15) Hormone X activates the cAMP second messenger system
in its target cells. The greatest response by a cell would come from
A) applying a molecule of hormone X to the extracellular
fluid surrounding the cell.
B) injecting a molecule of hormone X into the cytoplasm
of the cell.
C) applying a molecule of cAMP to the extracellular fluid
surrounding the cell.
D) injecting a molecule of cAMP into the cytoplasm of the
cell.
E) injecting a molecule of activated, cAMP-dependent
protein kinase into the cytoplasm of the cell.
Answer: A
16) When a steroid hormone and a peptide hormone exert
similar effects on a population of target cells, then
A) the steroid and peptide hormones must use the same
biochemical mechanisms.
B) the steroid and peptide hormones must bind to the same
receptor protein.
C) the steroid hormones affect the synthesis of effector
proteins, whereas peptide hormones activate effector proteins already present
in the cell.
D) the steroid hormones affect the activity of certain
proteins within the cell, whereas peptide hormones directly affect the
processing of mRNA.
E) the steroid hormones affect only the release of
proteins from the target cell, whereas peptide hormones affect only the
synthesis of proteins that remain in the target cell.
Answer: C
17) For hormones that homeostatically regulate cellular
functions,
A) negative feedback typically regulates hormone
secretion.
B) the circulating level of a hormone is held constant
through a series of positive feedback loops.
C) both lipid-soluble hormones and water-soluble hormones
bind to intracellular protein receptors.
D) endocrine organs release their contents into the
bloodstream via specialized ducts.
E) it is impossible to also have neural regulation of
that system.
Answer: A
18) Nitric oxide and epinephrine
A) both function as neurotransmitters.
B) both function as steroid hormones.
C) are both involved in the "fight-or-flight"
response.
D) bind the same receptors.
E) both cause a reduction in the blood levels of glucose.
Answer: A
19) Suppose that substance X is secreted by one cell,
travels via interstitial fluid to a neighboring cell, and produces an effect on
that cell. All of the following terms could describe this substance except
A) paracrine signal.
B) neurotransmitter.
C) prostaglandin.
D) pheromone.
E) growth factor.
Answer: D
20) Hormones that promote homeostasis
A) are not found as members of antagonistic signaling
mechanisms.
B) travel to target cells without passage in the plasma.
C) utilize receptors that bind any hormone.
D) initiate signal transduction in the target cell
without binding to receptors.
E) usually operate as part of a negative feedback system.
Answer: E
21) During mammalian labor and delivery, the contraction
of uterine muscles is enhanced by oxytocin. This is an example of
A) a negative feedback system.
B) a hormone that acts in an antagonistic way with
another hormone.
C) a hormone that is involved in a positive feedback
loop.
D) signal transduction immediately changing gene
expression in its target cells.
E) the key role of the anterior pituitary gland in
regulating uterine contraction.
Answer: C
22) During short-term starvation, most available fuel
molecules are catabolized to provide energy for metabolism rather than being
used as building blocks for growth and repair, a trade-off that is hormonally
regulated by
A) acetylcholine.
B) glucagon.
C) oxytocin.
D) antidiuretic hormone.
E) insulin.
Answer: B
23) Based on their effects, which pair below would not be
expected to be active at the same time and place?
A) prostaglandin F and nitric oxide
B) growth hormone and insulin-like growth factors
C) endocrine and exocrine glands
D) hormones and target cells
E) neurosecretory cells and neurotransmitters
Answer: A
24) The interrelationships between the endocrine and the
nervous systems are especially apparent in
A) a neuron in the spinal cord.
B) a steroid-producing cell in the adrenal cortex.
C) a neurosecretory cell in the hypothalamus.
D) a brain cell in the cerebral cortex.
E) a cell in the pancreas that produces digestive
enzymes.
Answer: C
25) The hypothalamus modulates hormone secretion by the
anterior pituitary by means of
A) peptide hormones.
B) steroid hormones.
C) electrical synapses.
D) neurotransmitters.
E) paracrine signals.
Answer: A
26) Portal blood vessels connect two capillary beds found
in the
A) hypothalamus and thalamus.
B) anterior pituitary and posterior pituitary.
C) hypothalamus and anterior pituitary.
D) posterior pituitary and thyroid gland.
E) anterior pituitary and adrenal gland.
Answer: C
27) If a person loses a large amount of water in a short
period of time, he or she may die from dehydration. ADH can help reduce water
loss through its interaction with its target cells in the
A) anterior pituitary.
B) posterior pituitary.
C) adrenal gland.
D) bladder.
E) kidney.
Answer: E
28) The hypothalamus
A) functions only as an endocrine target, by having lots
of receptors on its cells.
B) functions only in neuronal transmission.
C) does not have any hormone receptors on its cells.
D) secretes tropic hormones that act directly on the
gonads.
E) includes neurosecretory cells that terminate in the
posterior pituitary.
Answer: E
29) Prolactin stimulates mammary gland growth and
development in mammals and regulates salt and water balance in freshwater fish.
Many scientists think that this wide range of functions indicates that
prolactin
A) is a nonspecific hormone.
B) has a unique mechanism for eliciting its effects.
C) is an evolutionarily conserved hormone.
D) is derived from two separate sources.
E) interacts with many different receptor molecules.
Answer: C
30) A product of the anterior pituitary gland that causes
color changes in its target cells is
A) FSH.
B) LH.
C) TSH.
D) MSH.
E) ACTH.
Answer: D
31) To prevent insect pests from maturing into
reproducing adults, pest controllers use synthetic agonists of
A) ecdysone.
B) juvenile hormone.
C) oxytocin.
D) brain hormone.
E) prothoracic hormone.
Answer: B
32) In a lactating mammal, the two hormones that promote
milk synthesis and milk release, respectively, are
A) prolactin and calcitonin.
B) prolactin and oxytocin.
C) follicle-stimulating hormone and luteinizing hormone.
D) luteinizing hormone and oxytocin.
E) prolactin and luteinizing hormone.
Answer: B
33) Oxytocin and antidiuretic hormone are synthesized in
the
A) hypothalamus.
B) adenohypophysis.
C) anterior pituitary.
D) adrenal cortex.
E) posterior pituitary.
Answer: A
34) Endocrine structures derived from nervous tissue include
the
A) thymus and the thyroid.
B) ovaries and the testes.
C) liver and the pancreas.
D) anterior pituitary gland and the adrenal cortex.
E) posterior pituitary gland and the adrenal medulla.
Answer: E
35) Iodine is added to table salt to help prevent
deficiencies of an essential mineral needed for the proper function of the
A) parathyroid glands.
B) adrenal glands.
C) thyroid glands.
D) the endocrine pancreas.
E) the exocrine pancreas.
Answer: C
36) A tropic hormone from the anterior pituitary gland
regulates the secretion of
A) parathyroid hormone.
B) calcitonin.
C) epinephrine.
D) thyroxine.
E) glucagon.
Answer: D
37) Which endocrine disorder is correctly matched with
the malfunctioning gland?
A) diabetes insipidus and the posterior pituitary gland
B) giantism and the posterior pituitary gland
C) goiter and the adrenal medulla
D) diabetes mellitus and the parathyroid glands
E) dwarfism and the adrenal cortex
Answer: A
38) One reason a person might be severely overweight is
due to
A) an undersecretion of thyroxine.
B) a defect in hormone release from the posterior
pituitary.
C) a lower than normal level of insulin-like growth
factors.
D) hyposecretion of oxytocin.
E) a higher than normal level of melatonin.
Answer: A
39) Fight-or-flight reactions include activation of
A) the parathyroid glands, leading to increased metabolic
rate.
B) the thyroid gland, leading to an increase in the blood
calcium concentration.
C) the anterior pituitary gland, leading to cessation of
gonadal function.
D) the adrenal medulla, leading to increased secretion of
epinephrine.
E) the pancreas, leading to a reduction in the blood
sugar concentration.
Answer: D
40) The endocrine glands include the
A) parathyroid glands.
B) salivary glands.
C) sweat glands.
D) sebaceous glands.
E) gallbladder.
Answer: A
41) The body's reaction to PTH (parathyroid hormone), a
reduction in plasma levels of calcium, can be opposed by
A) thyroxine.
B) epinephrine.
C) growth hormone.
D) calcitonin.
E) glucagon.
Answer: D
42) Which of the following has both endocrine and
exocrine activity?
A) the pituitary gland
B) parathyroid glands
C) salivary glands
D) the pancreas
E) adrenal glands
Answer: D
43) Linkage to membrane-bound receptor proteins on target
cells activates the typical actions of the
A) androgens.
B) glucocorticoids.
C) estrogens.
D) pancreatic hormones.
E) progestins.
Answer: D
44) Analysis of a blood sample from a fasting individual
who had not eaten for 24 hours would be expected to reveal high levels of
A) insulin.
B) glucagon.
C) secretin.
D) gastrin.
E) glucose.
Answer: B
45) When the beta cells of the pancreas release insulin
into the blood,
A) the blood glucose levels rise to a set point and
stimulate glucagon release.
B) the skeletal muscles and the adipose cells take up
glucose at a faster rate.
C) the liver catabolizes glycogen.
D) the alpha cells of the pancreas release glucose into
the blood.
E) the kidneys begin gluconeogenesis.
Answer: B
46) A chemical signal that has both endocrine and neural
roles is
A) parathyroid hormone.
B) calcitonin.
C) epinephrine.
D) acetylcholine.
E) ecdysone.
Answer: C
47) The amino acid tyrosine is a starting substrate for
the synthesis of
A) epinephrine.
B) steroid hormones.
C) parathyroid hormone.
D) vitamin D.
E) acetylcholine.
Answer: A
48) The autonomic nervous system includes an endocrine
gland known as the
A) ovary.
B) adrenal medulla.
C) adrenal cortex.
D) testis.
E) thyroid.
Answer: B
49) A disease that destroys the adrenal cortex should
lead to an increase in the plasma levels of
A) glucocorticoid hormones.
B) epinephrine.
C) adrenocorticotropic hormone (ACTH).
D) glucose.
E) acetylcholine.
Answer: C
50) During a stressful interval
A) TSH stimulates the adrenal cortex and medulla to
secrete acetylcholine.
B) the alpha cells of islets secrete insulin and
simultaneously the beta cells of the islets secrete glucagon.
C) ACTH stimulates the adrenal cortex, and neurons of the
sympathetic nervous system stimulate the adrenal medulla.
D) the posterior pituitary gland secretes more growth
hormones.
E) the calcium levels in the blood are increased due to
actions of two antagonistic hormones, epinephrine and norepinephrine.
Answer: C
51) In response to stress, the adrenal gland promotes the
synthesis of glucose from noncarbohydrate substrates via the action of the
steroid hormone
A) glucagon.
B) cortisol.
C) epinephrine.
D) thyroxine.
E) ACTH.
Answer: B
52) Melatonin is secreted by
A) the hypothalamus during the day.
B) the pineal gland during the night.
C) the autonomic nervous system during the winter.
D) the posterior pituitary gland during the day.
E) the thyroid gland during cold seasons.
Answer: B
53) Winter hibernation and spring reproduction in bears
are cued by seasonal changes in the secretion of
A) melatonin from the pineal gland.
B) melatonin from the hypothalamus.
C) thyroxine from the anterior pituitary gland.
D) acetylcholine from the pineal gland.
E) thyroid-stimulating hormone from the posterior
pituitary gland.
Answer: A
54) The steroid hormone that coordinates molting in
arthropods is
A) ecdysone.
B) glucagon.
C) thyroxine.
D) oxytocin.
E) growth hormone.
Answer: A
55) After eating a carbohydrate-rich meal, the mammalian
pancreas increases its secretion of
A) ecdysone.
B) glucagon.
C) thyroxine.
D) oxytocin.
E) insulin.
Answer: E
56) The higher level of metabolic activity typical of
nonhibernating temperate mammals during the winter months is due to increased
secretion of
A) ecdysone.
B) glucagon.
C) thyroxine.
D) oxytocin.
E) growth hormone.
Answer: C
57) The increased contraction of the human uterus during
labor and delivery is at least partially due to the actions of
A) ecdysone.
B) glucagon.
C) thyroxine.
D) oxytocin.
E) growth hormone.
Answer: D
58) Abnormally reduced somatic growth (dwarfism) can be a
consequence of decreased hormone secretion from the
A) kidneys.
B) pancreas.
C) adrenal gland.
D) posterior pituitary gland.
E) anterior pituitary gland.
Answer: E
59) DES is called an "endocrine disrupting
chemical" because it structurally resembles, and interferes with, the
endocrine secretions of the
A) pancreatic islet cells.
B) thyroid gland.
C) adrenal medulla.
D) ovaries.
E) hypothalamus.
Answer: D
60) Testosterone is an example of
A) an androgen.
B) an estrogen.
C) a progestin.
D) a catecholamine.
E) an adrenal steroid.
Answer: A
61) Estradiol is an example of
A) an androgen.
B) an estrogen.
C) a progestin.
D) a catecholamine.
E) a glucocorticoid.
Answer: B
62) Epinephrine is an example of
A) an androgen.
B) an estrogen.
C) a progestin.
D) a catecholamine.
E) a glucocorticoid.
Answer: D
63) In an experiment, rats' ovaries were removed
immediately after impregnation and then the rats were divided into two groups.
Treatments and results are summarized in the table. The results most likely
occurred because progesterone exerts an effect on the
A) general health of the rat.
B) size of the fetus.
C) metabolism of the uterus.
D) gestation period of rats.
E) number of eggs fertilized.
Answer: C
64) A fantasy movie features a caterpillar that never
matures into an adult, but simply gets larger and larger with each molt. It
might be possible that the caterpillar did not mature into an adult because of
A) a lack of ecdysone.
B) a lack of juvenile hormone.
C) a decreased level of ecdysone.
D) an increased level of juvenile hormone.
E) a lack of melatonin.
Answer: D
65) Which of the following is not an accurate statement?
A) Hormones are chemical messengers that travel to target
cells through the circulatory system.
B) Hormones often regulate homeostasis through
antagonistic functions.
C) Hormones of the same chemical class usually have the
same function.
D) Hormones are secreted by specialized cells usually
located in endocrine glands.
E) Hormones are often regulated through feedback loops.
Answer: C
66) An example of antagonistic hormones controlling
homeostasis is
A) thyroxine and parathyroid hormone in calcium balance.
B) insulin and glucagon in glucose metabolism.
C) progestins and estrogens in sexual differentiation.
D) epinephrine and norepinephrine in fight-or-flight
responses.
E) oxytocin and prolactin in milk production.
Answer: B
67) Growth factors are local regulators that
A) are produced by the anterior pituitary.
B) are modified fatty acids that stimulate bone and
cartilage growth.
C) are found on the surface of cancer cells and stimulate
abnormal cell division.
D) bind to cell-surface receptors and stimulate growth
and development of target cells.
E) convey messages between nerve cells.
Answer: D
68) Which hormone is incorrectly paired with its action?
A) oxytocinstimulates uterine
contractions during childbirth
B) thyroxinestimulates metabolic
processes
C) insulinstimulates glycogen
breakdown in the liver
D) ACTHstimulates the release of
glucocorticoids by the adrenal cortex
E) melatoninaffects biological
rhythms, seasonal reproduction
Answer: C
69) Steroid and peptide hormones typically have in common
A) the building blocks from which they are synthesized.
B) their solubility in cell membranes.
C) their requirement for travel through the bloodstream.
D) the location of their receptors.
E) their reliance on signal transduction in the cell.
Answer: C
70) Which of the following is the most likely explanation
for hypothyroidism in a patient whose iodine level is normal?
A) greater production of T₃ than of T₄
B) hyposecretion of TSH
C) hypersecretion of TSH
D) hypersecretion of MSH
E) a decrease in the thyroid secretion of calcitonin
Answer: B
71) Shortly after ingesting a big plate of
carbohydrate-rich pasta, you measure your blood's hormone levels. What results
would you expect, compared to before the meal?
A) high insulin, low glucagon
B) low insulin, low glucagon
C) high insulin, high glucagon
D) low insulin, high glucagon
E) low insulin, no change in glucagon
Answer: A
72) The relationship between the insect hormones
ecdysteroid and PTTH is an example of
A) an interaction of the endocrine and nervous systems.
B) homeostasis achieved by positive feedback.
C) how peptide-derived hormones have more widespread
effects than steroid hormones.
D) homeostasis maintained by antagonistic hormones.
E) competitive inhibition of a hormone receptor.
Answer: A
